|
Symbol Name ID |
Prkcd
protein kinase C, delta MGI:97598 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Reduced natural killer cell activity |
Absent isohemagglutinin level |
Increased circulating antibody level |
Autoimmune hemolytic anemia |
Decreased proportion of class-switched memory B cells |
Decreased proportion of memory B cells |
Increased proportion autoreactive unresponsive CD21-/low B cells |
Increased B cell count |
Autoimmune thrombocytopenia |
Recurrent sinusitis |
Recurrent upper respiratory tract infections |
Persistent EBV viremia |
Lymphadenopathy |
Follicular hyperplasia |
Generalized lymphadenopathy |
Mediastinal lymphadenopathy |
Splenomegaly |
Hepatosplenomegaly |
Recurrent otitis media |
Membranous nephropathy |
Recurrent urinary tract infections |
Decreased circulating complement C3 concentration |
Decreased circulating complement C4 concentration |
Autoimmunity |
Antinuclear antibody positivity |
Anticardiolipin IgG antibody positivity |
Recurrent infections |
Recurrent lower respiratory tract infections |
| Disease(s) Associated with PRKCD | ||||||||||||||||||||||||||||
| autoimmune lymphoproliferative syndrome type 3 |
| Mouse Phenotypes | immune system phenotype |
increased B cell apoptosis |
increased B cell proliferation |
increased susceptibility to induced colitis |
enlarged spleen |
increased transitional stage B cell number |
abnormal plasma cell differentiation |
decreased neutrophil cell number |
increased follicular B cell number |
increased marginal zone B cell number |
increased B cell number |
increased NK cell number |
increased spleen germinal center number |
abnormal neutrophil physiology |
abnormal immunoglobulin level |
increased IgA level |
increased IgG1 level |
increased IgM level |
abnormal Peyer's patch germinal center morphology |
abnormal lymph node germinal center morphology |
enlarged lymph nodes |
enhanced humoral immune response |
increased interleukin-6 secretion |
increased anti-nuclear antigen antibody level |
increased anti-chromatin antibody level |
increased acute inflammation |
glomerulonephritis |
abnormal response to transplant |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||
| PrkcdM1Btlr/PrkcdM1Btlr | |||||||||||||||||||||||||||||
| Prkcdm2Btlr/Prkcdm2Btlr | |||||||||||||||||||||||||||||
| Prkcdtm1.1Chou/Prkcdtm1.1Chou | |||||||||||||||||||||||||||||
| Prkcdtm1Kin/Prkcdtm1Kin | |||||||||||||||||||||||||||||
| Prkcdtm1Msg/Prkcdtm1Msg | |||||||||||||||||||||||||||||
| Prkcdtm1Qxu/Prkcdtm1Qxu | * | ||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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